METHYLISOTHIAZOLINONE (MIT) (primary CASRN is 2682-20-4)

CAS: 125794-71-0

How can this chemical affect my health?

Acute (Short Term) EffectsData sources

Toxic To Humans & Animals, priority yellow

Toxic to Humans & Animals – Can be fatal on contact, ingestion or inhalation for humans and other mammals.

Irritates the Skin – Can cause irritation or serious damage to the skin.

Irritates the Eyes – Can cause irritation or serious damage to the eye.

Chronic (Long Term) EffectsData sources

Sensitizes the Skin – Can lead to allergic reactions on the skin.

Endocrine Disruption – Can interfere with hormone communication between cells which controls metabolism, development, growth, reproduction and behavior (the endocrine system).

Other Health Effects – Can cause serious damage on contact or ingestion.

Data sources

[2682-20-4] 2-methyl-4-isothiazolin-3-one » Sensitizes the Skin

These sources refer to a group of compounds containing this chemical:

H317 - May cause an allergic skin reaction [Skin sensitization - Category 1]
EU - GHS (H-Statements) Annex 6 Table 3-1
European Union / European Commission (EU EC)
Sensitizing Substance Sh - Danger of skin sensitization
MAK
MAK Commission of Germany (Deutsche Forschungsgemeinschaft)
H317 - May cause an allergic skin reaction [Skin sensitization - Category 1]
GHS - Korea
Republic of Korea - National Institute of Environmental Research (NIER)
Skin sensitisation category 1
GHS - New Zealand
Te Mana Rauhī Taiao (New Zealand EPA)
H317 - May cause an allergic skin reaction [Skin sensitization - Category 1]
GHS - Australia
Safe Work Australia
Skin Sens. 1 - May cause an allergic skin reaction (modeled)
DK-EPA - Danish Advisory List
Danish Environmental Protection Agency (DK-EPA)
H317 - May cause an allergic skin reaction (unverified) [Skin sensitization - Category 1]
EU - Manufacturer REACH hazard submissions
European Union / European Commission (EU EC)

[2682-20-4] 2-methyl-4-isothiazolin-3-one » Endocrine Disruption

These sources refer to a group of compounds containing this chemical:

Potential Endocrine Disruptor
TEDX - Potential Endocrine Disruptors
The Endocrine Disruption Exchange (TEDX)

[2682-20-4] 2-methyl-4-isothiazolin-3-one » Other Health Effects

These sources refer to a group of compounds containing this chemical:

H335 - May cause respiratory irritation (unverified) [Specific target organ toxicity - single exposure; Respiratory tract irritation - Category 3]
EU - Manufacturer REACH hazard submissions
European Union / European Commission (EU EC)
H373 - May cause damage to organs through prolonged or repeated exposure (unverified) [Specific target organ toxicity - repeated exposure - Category 2]
EU - Manufacturer REACH hazard submissions
European Union / European Commission (EU EC)

Direct Hazard » Sensitizes the Skin

These sources refer directly to this chemical:

Potential Skin Allergens
SCJ - Potential Skin Allergens
SC Johnson

Inherent HazardsData sources

Restricted List – This chemical is on a list from an authoritative body recommending that its use be avoided.

Data sources

[2682-20-4] 2-methyl-4-isothiazolin-3-one » Restricted List

These sources refer to a group of compounds containing this chemical:

Precautionary list of substances recommended for avoidance
P&W - Precautionary List
Perkins+Will (P+W)
Substances selected for RMOA or hazard assessment
EU - PACT-RMOA Substances
European Union / European Commission (EU EC)
Antimicrobials
GSPI - Six Classes Precautionary List
Green Science Policy Institute (GSPI)
Ingredients that are Restricted for Use in Cosmetic Products
Health Canada - Cosmetic Ingredient Hotlist
Health Canada
High priority chemicals
Sephora - High Priority Chemicals
Sephora
Prohibited Chemicals
Credo Beauty's Restricted Substance List
Credo
Cosmetics & Personal Care Products
C2C Certified v4 Product Standard Restricted Substances List (RSL) - Effective July 1, 2022
Cradle to Cradle Products Innovation Institute (C2CPII)
Priority for Inclusion in the Living Building Challenge Red List
Living Building Challenge 4.0 - Red List of Materials & Chemicals - Effective April 1, 2024
International Living Future Institute (ILFI)
Food Contact Chemicals Database Version 5.0
Food Contact Chemicals Database (FCCdb)
Food Packaging Forum
Substances Restricted in Toys
The Toy Safety Directive
European Union / European Commission (EU EC)
Antimicrobials
GreenScreen Certified Standard for Food Service Ware RSL
Clean Production Action (CPA)
TSCA Commercially Active
TSCA Chemical Substance Inventory (Active-Inactive)
US Environmental Protection Agency (US EPA)
Preservatives-Antioxidants - Yellow Triangle (Best available in class but some hazard profile issues)
US EPA - DfE Safer Chemicals Ingredients list (SCIL)
US Environmental Protection Agency (US EPA)
Antimicrobials (Preservatives)
GreenScreen Certified Standard for Furniture & Fabrics Bronze RSL
Clean Production Action (CPA)
GADSL Declarable or Prohibited Substances (D/P)
Global Automotive Declarable Substance List (GADSL)
Global Automotive Stakeholder Group (GASG)
Antimicrobials (Preservatives)
GreenScreen Certified Standard for Medical Supplies & Devices Bronze RSL
Clean Production Action (CPA)
Antimicrobials (Preservatives)
GreenScreen Certified Standard for Medical Supplies & Devices Silver-Gold RSL
Clean Production Action (CPA)
Tier 2 Emerging Chemicals of Concern & Harmful to the Environment
Campaign for Safe Cosmetics’ Red List of Chemicals of Concern
Campaign for Safe Cosmetics
Tier 3 Asthmagens, Allergens, & Irritants
Campaign for Safe Cosmetics’ Red List of Chemicals of Concern
Campaign for Safe Cosmetics
DSL-all
EC - CEPA DSL
Environment Canada & Health Canada (EC)

Antimicrobials » Restricted List

These sources refer to a group of compounds containing this chemical:

Antimicrobials (Surface Pathogens)
GreenScreen Certified Standard for Medical Supplies & Devices Bronze RSL
Clean Production Action (CPA)
Antimicrobials (Surface Pathogens)
GreenScreen Certified Standard for Medical Supplies & Devices Silver-Gold RSL
Clean Production Action (CPA)

Biocidal Active Substances » Restricted List

These sources refer to a group of compounds containing this chemical:

Reportable Substances and Future Restrictions in Products
Apple Regulated Substances Specification
Apple Inc.

How does this chemical impact the environment?Data sources

Immediate Harm To Aquatic Ecosystems, priority orange

Immediate Harm to Aquatic Ecosystems – A single exposure may result in severe biological harm or death to fish or other aquatic organisms.

Long-term Harm To Aquatic Ecosystems, priority orange

Long-Term Harm to Aquatic Ecosystems – Long term exposure may result in irreversible harm to fish or other aquatic organisms.

Data sources

[2682-20-4] 2-methyl-4-isothiazolin-3-one » Immediate Harm to Aquatic Ecosystems

These sources refer to a group of compounds containing this chemical:

H400 - Very toxic to aquatic life [Hazardous to the aquatic environment (acute) - Category 1]
EU - GHS (H-Statements) Annex 6 Table 3-1
European Union / European Commission (EU EC)
H400 - Very toxic to aquatic life [Hazardous to the aquatic environment (acute) - Category 1]
GHS - Korea
Republic of Korea - National Institute of Environmental Research (NIER)
Aquatic Acute1 - Very toxic to aquatic life (modeled)
DK-EPA - Danish Advisory List
Danish Environmental Protection Agency (DK-EPA)
H400 - Very toxic to aquatic life (unverified) [Hazardous to the aquatic environment (acute) - Category 1]
EU - Manufacturer REACH hazard submissions
European Union / European Commission (EU EC)
Hazardous to the aquatic environment - acute category 1
GHS - New Zealand
Te Mana Rauhī Taiao (New Zealand EPA)

[2682-20-4] 2-methyl-4-isothiazolin-3-one » Long-Term Harm to Aquatic Ecosystems

These sources refer to a group of compounds containing this chemical:

H410 - Very toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment (chronic) - Category 1]
EU - GHS (H-Statements) Annex 6 Table 3-1
European Union / European Commission (EU EC)
H410 - Very toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment (chronic) - Category 1]
GHS - Korea
Republic of Korea - National Institute of Environmental Research (NIER)
H410 - Very toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment (chronic) - Category 1]
GHS - Australia
Safe Work Australia
H413 - May cause long lasting harmful effects to aquatic life (unverified) [Hazardous to the aquatic environment (chronic) - Category 4]
EU - Manufacturer REACH hazard submissions
European Union / European Commission (EU EC)
H410 - Very toxic to aquatic life with long lasting effects (unverified) [Hazardous to the aquatic environment (chronic) - Category 1]
EU - Manufacturer REACH hazard submissions
European Union / European Commission (EU EC)
H411 - Toxic to aquatic life with long lasting effects (unverified) [Hazardous to the aquatic environment (chronic) - Category 2]
EU - Manufacturer REACH hazard submissions
European Union / European Commission (EU EC)
Hazardous to the aquatic environment - chronic category 1
GHS - New Zealand
Te Mana Rauhī Taiao (New Zealand EPA)

What safer alternatives are available for this chemical?

Information on safer alternatives is currently fairly limited, and not easily accessible or linked to information on chemicals in the workplace. Where we have information on safer alternatives, ChemHAT will display links to existing case studies of safer alternatives for the chemical.