Likely to cause

Can cause

May cause

METHYLISOTHIAZOLINONE (MIT) (primary CASRN is 2682-20-4)

CAS: 125794-71-0

How can this chemical affect my health?

Acute (Short Term) Effects

Toxic To Humans & Animals, priority yellow

Toxic to Humans & Animals – Toxicity or fatality on contact, ingestion or inhalation to humans and other mammals.

Skin Irritation – Irritation or serious damage to the skin.

Eye Irritation – Irritation or serious damage to the eyes.

Data sources

[2682-20-4] 2-methyl-4-isothiazolin-3-one » Toxic to Humans & Animals

These sources refer to a group of compounds containing this chemical:

FIFRA Registered Pesticide
US EPA - OPP - Registered Pesticides
US Environmental Protection Agency (US EPA)
H301 - Toxic if swallowed [Acute toxicity (oral) - Category 3]
EU - GHS (H-Statements) Annex 6 Table 3-1
European Union / European Commission (EU EC)
H311 - Toxic in contact with skin [Acute toxicity (dermal) - Category 3]
EU - GHS (H-Statements) Annex 6 Table 3-1
European Union / European Commission (EU EC)
H330 - Fatal if inhaled [Acute toxicity (inhalation) - Category 1 or 2]
EU - GHS (H-Statements) Annex 6 Table 3-1
European Union / European Commission (EU EC)
H310 - Fatal in contact with skin [Acute toxicity (dermal) - Category 1]
GHS - Korea
Republic of Korea - National Institute of Environmental Research (NIER)
H330 - Fatal if inhaled [Acute toxicity (inhalation) - Category 2]
GHS - Korea
Republic of Korea - National Institute of Environmental Research (NIER)
H301 - Toxic if swallowed [Acute toxicity (oral) - Category 3]
GHS - Korea
Republic of Korea - National Institute of Environmental Research (NIER)
H301 - Toxic if swallowed [Acute toxicity (oral) - Category 3]
GHS - Australia
Safe Work Australia
H311 - Toxic in contact with skin [Acute toxicity (dermal) - Category 3]
GHS - Australia
Safe Work Australia
H330 - Fatal if inhaled [Acute toxicity (inhalation) - Category 1 or 2]
GHS - Australia
Safe Work Australia
Acute dermal toxicity category 2
GHS - New Zealand
Te Mana Rauhī Taiao (Aotearoa New Zealand EPA)
Acute inhalation toxicity category 2
GHS - New Zealand
Te Mana Rauhī Taiao (Aotearoa New Zealand EPA)
Acute oral toxicity category 2
GHS - New Zealand
Te Mana Rauhī Taiao (Aotearoa New Zealand EPA)

[2682-20-4] 2-methyl-4-isothiazolin-3-one » Skin Irritation

These sources refer to a group of compounds containing this chemical:

H314 - Causes severe skin burns and eye damage [Skin corrosion/irritation - Category 1A or 1B or 1C]
EU - GHS (H-Statements) Annex 6 Table 3-1
European Union / European Commission (EU EC)
H314 - Causes severe skin burns and eye damage [Skin corrosion/irritation - Category 1]
GHS - Korea
Republic of Korea - National Institute of Environmental Research (NIER)
Skin corrosion category 1B
GHS - New Zealand
Te Mana Rauhī Taiao (Aotearoa New Zealand EPA)
H314 - Causes severe skin burns and eye damage [Skin corrosion/irritation - Category 1A or 1B or 1C]
GHS - Australia
Safe Work Australia

[2682-20-4] 2-methyl-4-isothiazolin-3-one » Eye Irritation

These sources refer to a group of compounds containing this chemical:

H318 - Causes serious eye damage [Serious eye damage/eye irritation - Category 1]
EU - GHS (H-Statements) Annex 6 Table 3-1
European Union / European Commission (EU EC)
Serious eye damage category 1
GHS - New Zealand
Te Mana Rauhī Taiao (Aotearoa New Zealand EPA)

Chronic (Long Term) Effects

Skin Sensitization – Allergic skin reactions.

Endocrine Disruption – Interference with the endocrine system, which plays a crucial role in metabolism, development, growth, reproduction and behavior.

Data sources

[2682-20-4] 2-methyl-4-isothiazolin-3-one » Skin Sensitization

These sources refer to a group of compounds containing this chemical:

H317 - May cause an allergic skin reaction [Skin sensitization - Category 1]
EU - GHS (H-Statements) Annex 6 Table 3-1
European Union / European Commission (EU EC)
Sensitizing Substance Sh - Danger of skin sensitization
MAK
MAK Commission of Germany (Deutsche Forschungsgemeinschaft)
H317 - May cause an allergic skin reaction [Skin sensitization - Category 1]
GHS - Korea
Republic of Korea - National Institute of Environmental Research (NIER)
Skin sensitisation category 1
GHS - New Zealand
Te Mana Rauhī Taiao (Aotearoa New Zealand EPA)
H317 - May cause an allergic skin reaction [Skin sensitization - Category 1]
GHS - Australia
Safe Work Australia

[2682-20-4] 2-methyl-4-isothiazolin-3-one » Endocrine Disruption

These sources refer to a group of compounds containing this chemical:

Potential Endocrine Disruptor
TEDX - Potential Endocrine Disruptors
The Endocrine Disruption Exchange (TEDX)

Direct Hazard » Skin Sensitization

These sources refer directly to this chemical:

Potential Skin Allergens
SCJ - Potential Skin Allergens
SC Johnson

Inherent Hazards

Restricted List – This chemical is on a list from an authoritative body recommending that its use be avoided.

Data sources

[2682-20-4] 2-methyl-4-isothiazolin-3-one » Restricted List

These sources refer to a group of compounds containing this chemical:

Precautionary list of substances recommended for avoidance
P&W - Precautionary List
Perkins+Will (P+W)
Assessment of regulatory needs
EU - PACT-RMOA Substances
European Union / European Commission (EU EC)
Antimicrobials
GSPI - Six Classes Precautionary List
Green Science Policy Institute (GSPI)
Ingredients that are Restricted for Use in Cosmetic Products
Health Canada - Cosmetic Ingredient Hotlist
Health Canada
High priority chemicals
Sephora - High Priority Chemicals
Sephora
Prohibited Chemicals
Credo Beauty's Restricted Substance List
Credo
Cosmetics & Personal Care Products
C2C Certified v4.0 Product Standard Restricted Substances List (RSL) - Effective July 1, 2022
Cradle to Cradle Products Innovation Institute (C2CPII)
Priority for Inclusion in the Living Building Challenge Red List
Living Building Challenge 4.0 - Red List of Materials & Chemicals - Effective February 1, 2025
International Living Future Institute (ILFI)
Food Contact Chemicals Database Version 5.0
Food Contact Chemicals Database (FCCdb)
Food Packaging Forum
Substances Restricted in Toys
The Toy Safety Directive
European Union / European Commission (EU EC)
Antimicrobials
GreenScreen Certified Standard for Food Service Ware RSL
Clean Production Action (CPA)
TSCA Commercially Active
TSCA Chemical Substance Inventory (Active-Inactive)
US Environmental Protection Agency (US EPA)
Preservatives-Antioxidants - Yellow Triangle (Best available in class but some hazard profile issues)
US EPA - DfE Safer Chemicals Ingredients list (SCIL)
US Environmental Protection Agency (US EPA)
Antimicrobials (Preservatives)
GreenScreen Certified Standard for Furniture & Fabrics Bronze RSL
Clean Production Action (CPA)
GADSL Declarable or Prohibited Substances (D/P)
Global Automotive Declarable Substance List (GADSL)
Global Automotive Stakeholder Group (GASG)
Antimicrobials (Preservatives)
GreenScreen Certified Standard for Medical Supplies & Devices Bronze RSL
Clean Production Action (CPA)
Antimicrobials (Preservatives)
GreenScreen Certified Standard for Medical Supplies & Devices Silver-Gold RSL
Clean Production Action (CPA)
Tier 2 Emerging Chemicals of Concern & Harmful to the Environment
Campaign for Safe Cosmetics’ Red List of Chemicals of Concern
Campaign for Safe Cosmetics
Tier 3 Asthmagens, Allergens, & Irritants
Campaign for Safe Cosmetics’ Red List of Chemicals of Concern
Campaign for Safe Cosmetics
New Zealand Inventory of Chemicals (NZIoC)
New Zealand Inventory of Chemicals
Te Mana Rauhī Taiao (Aotearoa New Zealand EPA)
The Australian Inventory of Industrial Chemicals
The Australian Inventory of Industrial Chemicals
Australian Government
Existing Chemicals List
Korea Existing Chemicals List
Korea Ministry of Environment
IECSC-2013
The Inventory of Existing Chemical Substance in China - 2013
China's Ministry of Ecology and Environment
Philippine Inventory of Chemicals
Philippine Inventory of Chemicals
The Philippine Government
DSL-all
EC - CEPA DSL
Environment Canada & Health Canada (EC)
Taiwan Existing Chemical Substance Inventory
Taiwan Existing Chemical Substance Inventory
Taiwan Ministry of Environment
NICNAS
Australia - National Industrial Chemicals Notification and Assessments (NICNAS)
Australian Government
Cosmetics and Personal Care Products
C2C Certified v4.1 Product Standard Restricted Substances - Effective July 1, 2025
Cradle to Cradle Products Innovation Institute (C2CPII)
Regulatory risk management
EU - PACT-RMOA Substances
European Union / European Commission (EU EC)

Antimicrobials » Restricted List

These sources refer to a group of compounds containing this chemical:

Antimicrobials (Surface Pathogens)
GreenScreen Certified Standard for Medical Supplies & Devices Bronze RSL
Clean Production Action (CPA)
Antimicrobials (Surface Pathogens)
GreenScreen Certified Standard for Medical Supplies & Devices Silver-Gold RSL
Clean Production Action (CPA)

Skin Sensitising Substances - Apple Rss » Restricted List

These sources refer to a group of compounds containing this chemical:

Restricted Substances in Products
Apple Regulated Substances Specification
Apple Inc.

Biocidal Active Substances - Echa » Restricted List

These sources refer to a group of compounds containing this chemical:

Reportable Substances and Future Restrictions in Products
Apple Regulated Substances Specification
Apple Inc.

Antimicrobials Used In Building Products » Restricted List

These sources refer to a group of compounds containing this chemical:

Antimicrobials
Bora's Chemicals of Concern List
Bora Architecture & Interiors

How does this chemical impact the environment?

Acute Harm To Aquatic Ecosystems, priority orange

Acute Harm to Aquatic Ecosystems – Biological harm or possible death to fish or other aquatic organisms following a single exposure.

Chronic Harm To Aquatic Ecosystems, priority orange

Chronic Harm to Aquatic Ecosystems – Irreversible harm to fish or other aquatic organisms following long term exposure.

Data sources

[2682-20-4] 2-methyl-4-isothiazolin-3-one » Acute Harm to Aquatic Ecosystems

These sources refer to a group of compounds containing this chemical:

H400 - Very toxic to aquatic life [Hazardous to the aquatic environment (acute) - Category 1]
EU - GHS (H-Statements) Annex 6 Table 3-1
European Union / European Commission (EU EC)
H400 - Very toxic to aquatic life [Hazardous to the aquatic environment (acute) - Category 1]
GHS - Korea
Republic of Korea - National Institute of Environmental Research (NIER)
Hazardous to the aquatic environment - acute category 1
GHS - New Zealand
Te Mana Rauhī Taiao (Aotearoa New Zealand EPA)

[2682-20-4] 2-methyl-4-isothiazolin-3-one » Chronic Harm to Aquatic Ecosystems

These sources refer to a group of compounds containing this chemical:

H410 - Very toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment (chronic) - Category 1]
EU - GHS (H-Statements) Annex 6 Table 3-1
European Union / European Commission (EU EC)
H410 - Very toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment (chronic) - Category 1]
GHS - Korea
Republic of Korea - National Institute of Environmental Research (NIER)
H410 - Very toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment (chronic) - Category 1]
GHS - Australia
Safe Work Australia
Hazardous to the aquatic environment - chronic category 1
GHS - New Zealand
Te Mana Rauhī Taiao (Aotearoa New Zealand EPA)

What safer alternatives are available for this chemical?

Information on safer alternatives is currently fairly limited, and not easily accessible or linked to information on chemicals in the workplace. Where we have information on safer alternatives, ChemHAT will display links to existing case studies of safer alternatives for the chemical.

How am I likely to be exposed to this chemical?

Ingestion

Skin contact

Eye contact

Inhalation

How can I protect myself from exposure to this chemical in the workplace?

Handle with gloves

Protective clothing

Safety eyeware

Respirator