Stronger effect / evidence
redorangeyellowgray
Weaker effect / evidence

1,2-Benzisothiazoline-3-one

CAS: 2634-33-5

How can this chemical affect my health?

Acute (Short Term) EffectsData sources

Toxic To Humans & Animals, priority yellow
Toxic to Humans & Animals – Can be fatal on contact, ingestion or inhalation for humans and other mammals.
Irritates The Skin, priority yellow
Irritates the Skin – Can cause irritation or serious damage to the skin.
Irritates The Eyes, priority orange
Irritates the Eyes – Can cause irritation or serious damage to the eye.

Chronic (Long Term) EffectsData sources

Sensitizes The Skin, priority yellow
Sensitizes the Skin – Can lead to allergic reactions on the skin.
Other Health Effects, priority orange
Other Health Effects – Can cause serious damage on contact or ingestion.
Asthma Trigger, priority yellow
Asthma Trigger – Can result in high sensitivity so that small quantities trigger asthma, nose or sinus inflammation or other allergic reactions in the respiratory system.

Data sources

Direct Hazard » Sensitizes the Skin

These sources refer directly to this chemical:

  • H317 - May cause an allergic skin reaction [Skin sensitization - Category 1]
    EU - GHS (H-Statements) Annex 6 Table 3-1
    European Union / European Commission (EU EC)
  • Sensitizing Substance Sh - Danger of skin sensitization
    MAK
    MAK Commission of Germany (Deutsche Forschungsgemeinschaft)
  • Skin sensitisation category 1
    GHS - New Zealand
    Te Mana Rauhī Taiao (New Zealand EPA)
  • H317 - May cause an allergic skin reaction [Skin sensitization - Category 1]
    GHS - Australia
    Safe Work Australia
  • Potential Skin Allergens
    SCJ - Potential Skin Allergens
    SC Johnson
  • H317 - May cause an allergic skin reaction (unverified) [Skin sensitization - Category 1]
    EU - Manufacturer REACH hazard submissions
    European Union / European Commission (EU EC)

Direct Hazard » Other Health Effects

These sources refer directly to this chemical:

  • H371 - May cause damage to organs [Specific target organs/systemic toxicity following single exposure - Category 2]
    GHS - Japan
    Government of Japan

Direct Hazard » Asthma Trigger

These sources refer directly to this chemical:

  • Agent Causing Occupational Asthma
    Quebec CSST - Asthma Agents
    Québec Workplace Health and Safety Commission (Commission de la santé et de la securite du travail (CSST))
Close

Inherent HazardsData sources

Restricted List, priority gray
Restricted List – This chemical is on a list from an authoritative body recommending that its use be avoided.

Data sources

Direct Hazard » Restricted List

These sources refer directly to this chemical:

  • Precautionary list of substances recommended for avoidance
    P&W - Precautionary List
    Perkins+Will (P+W)
  • Substances selected for RMOA or hazard assessment
    EU - PACT-RMOA Substances
    European Union / European Commission (EU EC)
  • Antimicrobials
    GSPI - Six Classes Precautionary List
    Green Science Policy Institute (GSPI)
  • Priority for Inclusion in the Living Building Challenge Red List
    Living Building Challenge 4.0 - Red List of Materials & Chemicals - Effective April 1, 2023
    International Living Future Institute (ILFI)
  • Food Contact Chemicals Database Version 5.0
    Food Contact Chemicals Database (FCCdb)
    Food Packaging Forum
  • Food Contact Chemicals of Concern List (FCCoCL) - TIER 3
    Food Contact Chemicals of Concern (FCCoCL)
    Food Packaging Forum
  • Substances Restricted in Toys
    The Toy Safety Directive
    European Union / European Commission (EU EC)
  • FPF Priority Substance List from FCCdb
    FPF Priority Substance List from FCCdb
    Food Packaging Forum
  • Antimicrobials
    GreenScreen Certified Standard for Food Service Ware RSL
    Clean Production Action (CPA)
  • Food Packaging Forum Priority Substances List
    GreenScreen Certified Standard for Food Service Ware RSL
    Clean Production Action (CPA)
  • TSCA Chemical Substance Inventory - Active
    TSCA Chemical Substance Inventory (Active-Inactive)
    US Environmental Protection Agency (US EPA)
  • Preservatives-Antioxidants - Yellow Triangle (Best available in class but some hazard profile issues)
    US EPA - DfE Safer Chemicals Ingredients list (SCIL)
    US Environmental Protection Agency (US EPA)
  • Antimicrobials (Preservatives)
    GreenScreen Certified Standard for Furniture & Fabrics Bronze RSL
    Clean Production Action (CPA)
  • GADSL Declarable or Prohibited Substances (D/P)
    Global Automotive Declarable Substance List (GADSL)
    Global Automotive Stakeholder Group (GASG)
  • Antimicrobials (Preservatives)
    GreenScreen Certified Standard for Medical Supplies & Devices Bronze RSL
    Clean Production Action (CPA)
  • Antimicrobials (Preservatives)
    GreenScreen Certified Standard for Medical Supplies & Devices Silver-Gold RSL
    Clean Production Action (CPA)
  • DSL-all
    EC - CEPA DSL
    Environment Canada & Health Canada (EC)

Antimicrobials » Restricted List

These sources refer to a group of compounds containing this chemical:

  • Antimicrobials (Surface Pathogens)
    GreenScreen Certified Standard for Medical Supplies & Devices Bronze RSL
    Clean Production Action (CPA)
  • Antimicrobials (Surface Pathogens)
    GreenScreen Certified Standard for Medical Supplies & Devices Silver-Gold RSL
    Clean Production Action (CPA)

Biocidal Active Substances » Restricted List

These sources refer to a group of compounds containing this chemical:

  • Reportable Substances and Future Restrictions in Products
    Apple Regulated Substances Specification
    Apple Inc.
Close

How does this chemical impact the environment?Data sources

Immediate Harm To Aquatic Ecosystems, priority orange
Immediate Harm to Aquatic Ecosystems – A single exposure may result in severe biological harm or death to fish or other aquatic organisms.
Long-term Harm To Aquatic Ecosystems, priority orange
Long-Term Harm to Aquatic Ecosystems – Long term exposure may result in irreversible harm to fish or other aquatic organisms.

Data sources

Direct Hazard » Immediate Harm to Aquatic Ecosystems

These sources refer directly to this chemical:

  • H400 - Very toxic to aquatic life [Hazardous to the aquatic environment (acute) - Category 1]
    EU - GHS (H-Statements) Annex 6 Table 3-1
    European Union / European Commission (EU EC)
  • H400 - Very toxic to aquatic life [Hazardous to the aquatic environment (acute) - Category 1]
    GHS - Japan
    Government of Japan
  • H400 - Very toxic to aquatic life [Hazardous to the aquatic environment (acute) - Category 1]
    GHS - Australia
    Safe Work Australia
  • H400 - Very toxic to aquatic life (unverified) [Hazardous to the aquatic environment (acute) - Category 1]
    EU - Manufacturer REACH hazard submissions
    European Union / European Commission (EU EC)
  • Hazardous to the aquatic environment - acute category 1
    GHS - New Zealand
    Te Mana Rauhī Taiao (New Zealand EPA)

Direct Hazard » Long-Term Harm to Aquatic Ecosystems

These sources refer directly to this chemical:

  • H410 - Very toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment (chronic) - Category 1]
    GHS - Japan
    Government of Japan
  • H412 - Harmful to aquatic life with long lasting effects (unverified) [Hazardous to the aquatic environment (chronic) - Category 3]
    EU - Manufacturer REACH hazard submissions
    European Union / European Commission (EU EC)
  • H410 - Very toxic to aquatic life with long lasting effects (unverified) [Hazardous to the aquatic environment (chronic) - Category 1]
    EU - Manufacturer REACH hazard submissions
    European Union / European Commission (EU EC)
  • H411 - Toxic to aquatic life with long lasting effects (unverified) [Hazardous to the aquatic environment (chronic) - Category 2]
    EU - Manufacturer REACH hazard submissions
    European Union / European Commission (EU EC)
  • Hazardous to the aquatic environment - chronic category 1
    GHS - New Zealand
    Te Mana Rauhī Taiao (New Zealand EPA)
Close

What safer alternatives are available for this chemical?

Information on safer alternatives is currently fairly limited, and not easily accessible or linked to information on chemicals in the workplace. Where we have information on safer alternatives, ChemHAT will display links to existing case studies of safer alternatives for the chemical.

How am I likely to be exposed to this chemical?

Harmful if swallowed
Ingestion
Causes skin irritation
Skin contact
Causes serious eye damage
Eye contact

How can I protect myself from exposure to this chemical in the workplace?

gloves
Handle with gloves
glasses
Safety eyeware
suit
Protective clothing