Stronger effect / evidence
Weaker effect / evidence
1,2-Benzisothiazoline-3-one
CAS: 2634-33-5
How can this chemical affect my health?
Acute (Short Term) EffectsData sources
Toxic to Humans & Animals – Can be fatal on contact, ingestion or inhalation for humans and other mammals.
Irritates the Skin – Can cause irritation or serious damage to the skin.
Irritates the Eyes – Can cause irritation or serious damage to the eye.
Data sources
Direct Hazard » Toxic to Humans & Animals
These sources refer directly to this chemical:
- FIFRA Registered PesticideUS EPA - OPP - Registered PesticidesUS Environmental Protection Agency (US EPA)
- H302 - Harmful if swallowed [Acute toxicity (oral) - Category 4]EU - GHS (H-Statements) Annex 6 Table 3-1European Union / European Commission (EU EC)
- H330 - Fatal if inhaled [Acute toxicity (inhalation: dust, mist) - Category 2]GHS - JapanGovernment of Japan
- H302 - Harmful if swallowed [Acute Toxicity (oral) - Category 4]GHS - JapanGovernment of Japan
- H302 - Harmful if swallowed [Acute toxicity (oral) - Category 4]GHS - AustraliaSafe Work Australia
- H302 - Harmful if swallowed (unverified) [Acute toxicity (oral) - Category 4]EU - Manufacturer REACH hazard submissionsEuropean Union / European Commission (EU EC)
- H330 - Fatal if inhaled (unverified) [Acute toxicity (inhalation) - Category 1 or 2]EU - Manufacturer REACH hazard submissionsEuropean Union / European Commission (EU EC)
- Acute oral toxicity category 4GHS - New ZealandTe Mana Rauhī Taiao (New Zealand EPA)
Direct Hazard » Irritates the Skin
These sources refer directly to this chemical:
- H315 - Causes skin irritation [Skin corrosion/irritation - Category 2]EU - GHS (H-Statements) Annex 6 Table 3-1European Union / European Commission (EU EC)
- Skin irritation category 2GHS - New ZealandTe Mana Rauhī Taiao (New Zealand EPA)
- H315 - Causes skin irritation [Skin corrosion / irritation - Category 2]GHS - JapanGovernment of Japan
- H315 - Causes skin irritation [Skin corrosion/irritation - Category 2]GHS - AustraliaSafe Work Australia
- H315 - Causes skin irritation (unverified) [Skin corrosion/irritation - Category 2]EU - Manufacturer REACH hazard submissionsEuropean Union / European Commission (EU EC)
Direct Hazard » Irritates the Eyes
These sources refer directly to this chemical:
- H318 - Causes serious eye damage [Serious eye damage/eye irritation - Category 1]EU - GHS (H-Statements) Annex 6 Table 3-1European Union / European Commission (EU EC)
- Serious eye damage category 1GHS - New ZealandTe Mana Rauhī Taiao (New Zealand EPA)
- H318 - Causes serious eye damage [Serious eye damage / eye irritation - Category 1]GHS - JapanGovernment of Japan
- H318 - Causes serious eye damage [Serious eye damage/eye irritation - Category 1]GHS - AustraliaSafe Work Australia
- H318 - Causes serious eye damage (unverified) [Serious eye damage/eye irritation - Category 1]EU - Manufacturer REACH hazard submissionsEuropean Union / European Commission (EU EC)
Chronic (Long Term) EffectsData sources
Sensitizes the Skin – Can lead to allergic reactions on the skin.
Other Health Effects – Can cause serious damage on contact or ingestion.
Asthma Trigger – Can result in high sensitivity so that small quantities trigger asthma, nose or sinus inflammation or other allergic reactions in the respiratory system.
Data sources
Direct Hazard » Sensitizes the Skin
These sources refer directly to this chemical:
- H317 - May cause an allergic skin reaction [Skin sensitization - Category 1]EU - GHS (H-Statements) Annex 6 Table 3-1European Union / European Commission (EU EC)
- Sensitizing Substance Sh - Danger of skin sensitizationMAKMAK Commission of Germany (Deutsche Forschungsgemeinschaft)
- Skin sensitisation category 1GHS - New ZealandTe Mana Rauhī Taiao (New Zealand EPA)
- H317 - May cause an allergic skin reaction [Skin sensitization - Category 1]GHS - AustraliaSafe Work Australia
- Potential Skin AllergensSCJ - Potential Skin AllergensSC Johnson
- H317 - May cause an allergic skin reaction (unverified) [Skin sensitization - Category 1]EU - Manufacturer REACH hazard submissionsEuropean Union / European Commission (EU EC)
Direct Hazard » Other Health Effects
These sources refer directly to this chemical:
- H371 - May cause damage to organs [Specific target organs/systemic toxicity following single exposure - Category 2]GHS - JapanGovernment of Japan
Direct Hazard » Asthma Trigger
These sources refer directly to this chemical:
- Agent Causing Occupational AsthmaQuebec CSST - Asthma AgentsQuébec Workplace Health and Safety Commission (Commission de la santé et de la securite du travail (CSST))
Inherent HazardsData sources
Restricted List – This chemical is on a list from an authoritative body recommending that its use be avoided.
Data sources
Direct Hazard » Restricted List
These sources refer directly to this chemical:
- Precautionary list of substances recommended for avoidanceP&W - Precautionary ListPerkins+Will (P+W)
- Substances selected for RMOA or hazard assessmentEU - PACT-RMOA SubstancesEuropean Union / European Commission (EU EC)
- AntimicrobialsGSPI - Six Classes Precautionary ListGreen Science Policy Institute (GSPI)
- Priority for Inclusion in the Living Building Challenge Red ListLiving Building Challenge 4.0 - Red List of Materials & Chemicals - Effective April 1, 2023International Living Future Institute (ILFI)
- Food Contact Chemicals Database Version 5.0Food Contact Chemicals Database (FCCdb)Food Packaging Forum
- Food Contact Chemicals of Concern List (FCCoCL) - TIER 3Food Contact Chemicals of Concern (FCCoCL)Food Packaging Forum
- Substances Restricted in ToysThe Toy Safety DirectiveEuropean Union / European Commission (EU EC)
- FPF Priority Substance List from FCCdbFPF Priority Substance List from FCCdbFood Packaging Forum
- AntimicrobialsGreenScreen Certified Standard for Food Service Ware RSLClean Production Action (CPA)
- Food Packaging Forum Priority Substances ListGreenScreen Certified Standard for Food Service Ware RSLClean Production Action (CPA)
- TSCA Chemical Substance Inventory - ActiveTSCA Chemical Substance Inventory (Active-Inactive)US Environmental Protection Agency (US EPA)
- Preservatives-Antioxidants - Yellow Triangle (Best available in class but some hazard profile issues)US EPA - DfE Safer Chemicals Ingredients list (SCIL)US Environmental Protection Agency (US EPA)
- Antimicrobials (Preservatives)GreenScreen Certified Standard for Furniture & Fabrics Bronze RSLClean Production Action (CPA)
- GADSL Declarable or Prohibited Substances (D/P)Global Automotive Declarable Substance List (GADSL)Global Automotive Stakeholder Group (GASG)
- Antimicrobials (Preservatives)GreenScreen Certified Standard for Medical Supplies & Devices Bronze RSLClean Production Action (CPA)
- Antimicrobials (Preservatives)GreenScreen Certified Standard for Medical Supplies & Devices Silver-Gold RSLClean Production Action (CPA)
- DSL-allEC - CEPA DSLEnvironment Canada & Health Canada (EC)
Antimicrobials » Restricted List
These sources refer to a group of compounds containing this chemical:
- Antimicrobials (Surface Pathogens)GreenScreen Certified Standard for Medical Supplies & Devices Bronze RSLClean Production Action (CPA)
- Antimicrobials (Surface Pathogens)GreenScreen Certified Standard for Medical Supplies & Devices Silver-Gold RSLClean Production Action (CPA)
Biocidal Active Substances » Restricted List
These sources refer to a group of compounds containing this chemical:
- Reportable Substances and Future Restrictions in ProductsApple Regulated Substances SpecificationApple Inc.
How does this chemical impact the environment?Data sources
Immediate Harm to Aquatic Ecosystems – A single exposure may result in severe biological harm or death to fish or other aquatic organisms.
Long-Term Harm to Aquatic Ecosystems – Long term exposure may result in irreversible harm to fish or other aquatic organisms.
Data sources
Direct Hazard » Immediate Harm to Aquatic Ecosystems
These sources refer directly to this chemical:
- H400 - Very toxic to aquatic life [Hazardous to the aquatic environment (acute) - Category 1]EU - GHS (H-Statements) Annex 6 Table 3-1European Union / European Commission (EU EC)
- H400 - Very toxic to aquatic life [Hazardous to the aquatic environment (acute) - Category 1]GHS - JapanGovernment of Japan
- H400 - Very toxic to aquatic life [Hazardous to the aquatic environment (acute) - Category 1]GHS - AustraliaSafe Work Australia
- H400 - Very toxic to aquatic life (unverified) [Hazardous to the aquatic environment (acute) - Category 1]EU - Manufacturer REACH hazard submissionsEuropean Union / European Commission (EU EC)
- Hazardous to the aquatic environment - acute category 1GHS - New ZealandTe Mana Rauhī Taiao (New Zealand EPA)
Direct Hazard » Long-Term Harm to Aquatic Ecosystems
These sources refer directly to this chemical:
- H410 - Very toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment (chronic) - Category 1]GHS - JapanGovernment of Japan
- H412 - Harmful to aquatic life with long lasting effects (unverified) [Hazardous to the aquatic environment (chronic) - Category 3]EU - Manufacturer REACH hazard submissionsEuropean Union / European Commission (EU EC)
- H410 - Very toxic to aquatic life with long lasting effects (unverified) [Hazardous to the aquatic environment (chronic) - Category 1]EU - Manufacturer REACH hazard submissionsEuropean Union / European Commission (EU EC)
- H411 - Toxic to aquatic life with long lasting effects (unverified) [Hazardous to the aquatic environment (chronic) - Category 2]EU - Manufacturer REACH hazard submissionsEuropean Union / European Commission (EU EC)
- Hazardous to the aquatic environment - chronic category 1GHS - New ZealandTe Mana Rauhī Taiao (New Zealand EPA)
What safer alternatives are available for this chemical?
Information on safer alternatives is currently fairly limited, and not easily accessible or linked to information on chemicals in the workplace. Where we have information on safer alternatives, ChemHAT will display links to existing case studies of safer alternatives for the chemical.
How am I likely to be exposed to this chemical?
Ingestion
Skin contact
Eye contact
How can I protect myself from exposure to this chemical in the workplace?
Handle with gloves
Safety eyeware
Protective clothing