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Weaker effect / evidence

Tri-(2-chloroisopropyl)phosphate

CAS: 13674-84-5

How can this chemical affect my health?

Acute (Short Term) EffectsData sources

Toxic To Humans & Animals, priority yellow
Toxic to Humans & Animals – Can be fatal on contact, ingestion or inhalation for humans and other mammals.

Chronic (Long Term) EffectsData sources

Endocrine Disruption, priority orange
Endocrine Disruption – Can interfere with hormone communication between cells which controls metabolism, development, growth, reproduction and behavior (the endocrine system).
Pbt (persistent Bioaccumulative Toxicant), priority red
PBT (Persistent Bioaccumulative Toxicant) – Does not break down readily from natural processes, accumulates in organisms concentrating as it moves up the food chain, and is harmful in small quantities.
Reproductive Harm, priority orange
Reproductive Harm – Can disrupt the male or female reproductive systems, changing sexual development, behavior or functions, decreasing fertility, or resulting in loss of the fetus during pregnancy.
Other Health Effects, priority yellow
Other Health Effects – Can cause serious damage on contact or ingestion.
Asthma Trigger, priority orange
Asthma Trigger – Can result in high sensitivity so that small quantities trigger asthma, nose or sinus inflammation or other allergic reactions in the respiratory system.

Data sources

Direct Hazard » Endocrine Disruption

These sources refer directly to this chemical:

  • Potential Endocrine Disruptor
    TEDX - Potential Endocrine Disruptors
    The Endocrine Disruption Exchange (TEDX)

Direct Hazard » Reproductive Harm

These sources refer directly to this chemical:

  • H361 - Suspected of damaging fertility or the unborn child [Toxic to reproduction - Category 2]
    GHS - Japan
    Government of Japan
  • H361fd - Suspected of damaging fertility. Suspected of damaging the unborn child [Reproductive toxicity - Category 2]
    GHS - Australia
    Safe Work Australia
  • Repr. 2; H361 - Suspected of damaging fertility or the unborn child (modeled)
    DK-EPA - Danish Advisory List
    Danish Environmental Protection Agency (DK-EPA)

Direct Hazard » Other Health Effects

These sources refer directly to this chemical:

  • H373 - May cause damage to organs through prolonged or repeated exposure [Specific target organs/systemic toxicity following repeated exposure - Category 2]
    GHS - Japan
    Government of Japan
  • H371 - May cause damage to organs [Specific target organs/systemic toxicity following single exposure - Category 2]
    GHS - Japan
    Government of Japan

Chlorinated Flame Retardants (cfrs) » PBT (Persistent Bioaccumulative Toxicant)

These sources refer to a group of compounds containing this chemical:

  • Flame retardant substance class of concern for PB&T & long range transport
    EHP - San Antonio Statement on BFRs & CFRs
    Environmental Health Perspectives

Organophosphorous Compounds » Asthma Trigger

These sources refer to a group of compounds containing this chemical:

  • Asthma - irritant - good evidence
    CHE - Toxicant Database
    Collaborative on Health and the Environment (CHE)

[1244733-77-4] Tris(2-chloroisopropyl) Phosphate (primary Casrn Is 13674-84-5) » Endocrine Disruption

These sources refer to a group of compounds containing this chemical:

  • ECHA Endocrine disruptor assessment list
    ECHA Endocrine Disruptors
    European Union / European Commission (EU EC)
  • ED List II - Substances under evaluation for endocrine disruption under an EU legislation
    Endocrine Disruptor Lists (Danish EPA)
    Danish Environmental Protection Agency (DK-EPA)
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Inherent HazardsData sources

Restricted List, priority gray
Restricted List – This chemical is on a list from an authoritative body recommending that its use be avoided.

Data sources

Chlorinated Flame Retardants (cfrs) » Restricted List

These sources refer to a group of compounds containing this chemical:

  • Red List substance to avoid in Living Building Challenge V2.1 projects
    Living Building Challenge 2.1 - Red List of Materials & Chemicals (retired in 2014)
    International Living Future Institute (ILFI)
  • Substance to avoid to fulfill LEED Pilot Credit 11
    USGBC - LEED Pilot Credits
    US Green Building Council (USGBC)
  • Prospective Red List substances to avoid in Living Building Challenge projects
    Living Building Challenge 3.0 - Red List of Materials & Chemicals (retiring December 31, 2024)
    International Living Future Institute (ILFI)

Direct Hazard » Restricted List

These sources refer directly to this chemical:

  • Precautionary list of substances recommended for avoidance
    P&W - Precautionary List
    Perkins+Will (P+W)
  • Chemicals of high concern
    SCHF - Hazardous 100
    Safer Chemicals, Healthy Families (SCHF)
  • Candidate Chemical List
    CA SCP - Candidate Chemicals
    California Department of Toxic Substance Control (CA DTSC)
  • Red List substances to avoid in Living Building Challenge V3 projects
    Living Building Challenge 3.0 - Red List of Materials & Chemicals (retiring December 31, 2024)
    International Living Future Institute (ILFI)
  • Substances selected for RMOA or hazard assessment
    EU - PACT-RMOA Substances
    European Union / European Commission (EU EC)
  • Some Solvents
    GSPI - Six Classes of Problematic Chemicals
    Green Science Policy Institute (GSPI)
  • Chemicals of High Concern
    MDH - Chemicals of High Concern and Priority Chemicals
    Minnesota Department of Public Health
  • Chemicals of High Concern to Children
    WA DoE - Chemicals of High Concern to Children
    Washington State Department of Ecology (WA DOE)
  • Designated Chemical
    CA DTSC - Biomonitoring California Chemical List
    California Department of Toxic Substance Control (CA DTSC)
  • Red List substances to avoid in Living Building Challenge V3.1 projects
    Living Building Challenge 3.1 - Red List of Materials & Chemicals (retiring December 31, 2024)
    International Living Future Institute (ILFI)
  • Red List substances to avoid in Living Building Challenge V4.0 projects
    Living Building Challenge 4.0 - Red List of Materials & Chemicals - Effective April 1, 2023
    International Living Future Institute (ILFI)
  • Declarable and Reference Substance Lists (DSL and RSL)
    IEC 62474 - Material Declaration for Products of and for the Electrotechnical Industry
    International Electrotechnical Commission
  • Chemicals of High Concern to Children
    Vermont Chemicals of High Concern to Children
    Vermont Environmental Health Division
  • Food Contact Chemicals Database Version 5.0
    Food Contact Chemicals Database (FCCdb)
    Food Packaging Forum
  • Substances Restricted in Toys
    The Toy Safety Directive
    European Union / European Commission (EU EC)
  • Flame Retardants
    American Apparel and Footwear Association Restricted Substance List (AAFA RSL)
    American Apparel and Footwear Association
  • ZDHC - MRSL v2.0
    ZDHC - MRSL v2.0
    Zero Discharge of Hazardous Waste Chemicals Programme
  • TSCA Chemical Substance Inventory - Active
    TSCA Chemical Substance Inventory (Active-Inactive)
    US Environmental Protection Agency (US EPA)
  • Flame Retardants (Non-electronic)
    GreenScreen Certified Standard for Furniture & Fabrics Bronze RSL
    Clean Production Action (CPA)
  • Halogenated Flame Retardants (Electronics)
    GreenScreen Certified Standard for Furniture & Fabrics Bronze RSL
    Clean Production Action (CPA)
  • Flame Retardants (Non-electronic)
    GreenScreen Certified Standard for Furniture & Fabrics Silver-Gold RSL
    Clean Production Action (CPA)
  • Halogenated Flame Retardants (Electronics)
    GreenScreen Certified Standard for Furniture & Fabrics Silver-Gold RSL
    Clean Production Action (CPA)
  • GADSL Declarable Substances - Information is being collected for a non-regulatory purpose (D/FI)
    Global Automotive Declarable Substance List (GADSL)
    Global Automotive Stakeholder Group (GASG)
  • Halogenated Flame Retardants (Bronze)
    GreenScreen Certified Standard for Medical Supplies & Devices Bronze RSL
    Clean Production Action (CPA)
  • Halogenated Flame Retardants
    GreenScreen Certified Standard for Medical Supplies & Devices Silver-Gold RSL
    Clean Production Action (CPA)
  • Potential CHRONIC health effects (over time or long-term)
    OR OHA - High Priority Chemicals of Concern for Children's Health (HPCCCH)
    Oregon Health Authority

Halogenated Flame Retardants (hfrs) » Restricted List

These sources refer to a group of compounds containing this chemical:

  • Substance to avoid to fulfill LEED Pilot Credit 54 Option 2
    USGBC - LEED Pilot Credits
    US Green Building Council (USGBC)

Flame Retardants » Restricted List

These sources refer to a group of compounds containing this chemical:

  • Priority Chemicals
    ME DEP - Chemicals of High Concern and Priority Chemicals
    Maine Department of Environmental Protection

Organophosphate Ester Flame Retardants (ope Fr) » Restricted List

These sources refer to a group of compounds containing this chemical:

  • Core Restrictions
    C2C Certified v4 Product Standard Restricted Substances List (RSL) - Effective July 1, 2022
    Cradle to Cradle Products Innovation Institute (C2CPII)

[98112-32-4] Tri(chloropropyl) Phosphate (primary Casrn Is 13674-84-5) » Restricted List

These sources refer to a group of compounds containing this chemical:

  • Watch List Substances Considered for Inclusion in the Living Building Challenge Red List
    Living Building Challenge 4.0 - Red List of Materials & Chemicals - Effective April 1, 2023
    International Living Future Institute (ILFI)

Chlorinated Organic Compounds » Restricted List

These sources refer to a group of compounds containing this chemical:

  • Chlorinated Organic Compounds
    GreenScreen Certified Standard for Cleaners & Degreasers RSL
    Clean Production Action (CPA)

Halogenated Organic Compounds » Restricted List

These sources refer to a group of compounds containing this chemical:

  • Organohalogens (including chlorinated plastics)
    GreenScreen Certified Standard for Food Service Ware RSL
    Clean Production Action (CPA)
  • Organohalogens
    GreenScreen Certified Standard for Medical Supplies & Devices Silver-Gold RSL
    Clean Production Action (CPA)
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How does this chemical impact the environment?Data sources

Persistent, priority red
Persistent – Does not break down readily from natural processes.
Immediate Harm To Aquatic Ecosystems, priority yellow
Immediate Harm to Aquatic Ecosystems – A single exposure may result in severe biological harm or death to fish or other aquatic organisms.
Long-term Harm To Aquatic Ecosystems, priority yellow
Long-Term Harm to Aquatic Ecosystems – Long term exposure may result in irreversible harm to fish or other aquatic organisms.

Data sources

Direct Hazard » Persistent

These sources refer directly to this chemical:

  • Persistent
    EC - CEPA DSL
    Environment Canada & Health Canada (EC)
  • Persistent, Mobile and Toxic
    ChemSec - SIN List
    ChemSec, The International Chemical Secretariat

Direct Hazard » Immediate Harm to Aquatic Ecosystems

These sources refer directly to this chemical:

  • H402 - Harmful to aquatic life [Hazardous to the aquatic environment (acute) - Category 3]
    GHS - Japan
    Government of Japan
  • Aquatic Acute1 - Very toxic to aquatic life (modeled)
    DK-EPA - Danish Advisory List
    Danish Environmental Protection Agency (DK-EPA)

Direct Hazard » Long-Term Harm to Aquatic Ecosystems

These sources refer directly to this chemical:

  • H412 - Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment (chronic) - Category 3]
    GHS - Japan
    Government of Japan
  • H412 - Harmful to aquatic life with long lasting effects (unverified) [Hazardous to the aquatic environment (chronic) - Category 3]
    EU - Manufacturer REACH hazard submissions
    European Union / European Commission (EU EC)
  • Hazardous to the aquatic environment - chronic category 3
    GHS - New Zealand
    New Zealand Environmental Protection Authority (NZ EPA)
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What safer alternatives are available for this chemical?

Information on safer alternatives is currently fairly limited, and not easily accessible or linked to information on chemicals in the workplace. Where we have information on safer alternatives, ChemHAT will display links to existing case studies of safer alternatives for the chemical.